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KMID : 1146920230530020249
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Journal of Pharmaceutical Investigation
2023 Volume.53 No. 2 p.249 ~ p.267
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Advanced technology using supercritical fluid for particle production in pharmaceutical continuous manufacturing
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Ha Eun-Sol
Kang Hui-Taek
Park Hee-Jun
Kim Se-Bin
Kim Min-Soo
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Abstract
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Background : In the pharmaceutical industry, supercritical fluid (SCF), particularly supercritical carbon dioxide (SC-CO2), can be utilized as a solvent, extractant, liquid expander, plasticizer, and aerosol. SCF-based particle formation technology, an environmentally friendly technology, has been used in the field of drug development to overcome solubility/dissolution issues of poorly water-soluble drugs and/or improve bioavailability without changing pharmacological activity. However, these technologies have limitations, such as operation in batch or semi-continuous mode and particle collection, and expert suggestions are required to resolve these issues.
Area covered : Advanced SCF technologies that use the unique properties of SC-CO2 to improve drug delivery and overcome the limitations of conventional supercritical solid particle formation technologies are summarized in this review.
Expert opinion : Advanced SCF technology can present a new paradigm for efficient formulation development and product manufacturing and is expected to become a new promising industrial strategy in the pharmaceutical aspect. Despite these advantages, it is difficult to develop commercial products because of the high investment cost and lack of research data; thus, additional research and interest are still needed.
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KEYWORD
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Advanced supercritical fluid technology, Particle formation, Continuous process, Drug delivery, Eco-friendly
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